荨麻疹患者与特异性IgE抗体相关性的研究

Discussion of the Relationship between Specific IgE Antibodies and Urticaria

目的探讨荨麻疹的致病因素,了解荨麻疹与过敏原的相互关系。方法采用酶免疫法过敏原体外检测试剂盒,对288例荨麻疹患者和35例健康对照者血清中特异性IgE抗体进行测定。结果288例荨麻疹患者中有212例.73.6%)至少有一项过敏原阳性,明显高于健康对照组的11.4%(P<0.01)。食入性和吸入性过敏原同时阳性占28.1%,2种或2种以上过敏原阳性占47.9%,吸入性过敏原中屋尘和尘(粉)螨阳性率最高,食入性过敏原则以螃蟹、虾、龙虾最敏感。少儿组对屋尘和尘(粉)螨的阳性率明显高于成人组(P<0.01)。结论荨麻疹与接触性过敏原特异性IgE抗体具有相关性。

Objective To investigate the relationship of serum specific IgE antibodies and urticaria in the pathogenesis of urticaria. Methods The serum specific IgE antibodies to contact allergens were tested by EIA kit in the sera from 288 cases of urticaria and 35 healthy controls. Results Out of 288 cases of urticaria,73.6% of patients were positive with specific IgE antibodies,compared with 11.4% in healthy groups,there was significant difference between two groups （P〈0. 01）. 28.1% patients were found positive in food and inhalant allergens at the same time. There were uqwards two of allergens positive in 47.9% patients. The most inhalant allergens were dust of house and dust （powder）mite. The most food allergens were crab,shrimp and lobster. Comparison the positive rate of dust of house and dust （powder） mite between the children and adult groups showed significant difference（P〈0. 01）. Conclusion There is relationship between the serum specific IgE antibodies to contact allergens and urticaria.