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新辅助化疗后乳腺癌中CerbB-2的表达及意义 被引量：3

新辅助化疗后乳腺癌中CerbB-2的表达及意义
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摘要 目的探讨新辅助化疗后乳腺癌标本CerbB-2的表达及意义。方法采用免疫组织化学法分别检测CerbB-2在131例新辅助化疗组及78例未化疗组乳腺癌组织中的表达状况,并分析CerbB-2的表达与新辅助化疗的关系。结果乳腺癌新辅助化疗组CerbB-2表达率低于未化疗组;新辅助化疗组中有效组与无效组表达率差异无显著性。结论CerbB-2可能作为乳腺癌治疗的一个靶点。 Objective To explore the expression and significance of CerbB - 2 in breast cancer after neoadjuvant chemotherapy. Methods The expression of CerbB - 2 was detected by immunohistochemisty in the specimens from 131 breast cancer patients with neoadjuvant chemotherapy （NAC group） and 78 breast cancer patients without neoadjuvant chemotherapy （non - NAC group）. The relationship between the level of expression of CerbB - 2 and neoadjuvant chemotherapy was also studied. Results The level of expression of CerbB - 2 in NAC group was less than that in non - NAC group. Conclusion CerbB - 2 may be an new target for breast cancer therapy.
作者 俞洋 杨红健 邹德宏
机构地区 浙江省肿瘤医院乳腺科
出处 《浙江临床医学》 2006年第1期3-4,共2页 Zhejiang Clinical Medical Journal
关键词 乳腺癌 新辅助化疗 CERBB-2 乳腺癌组织 化疗后 免疫组织化学法 表达状况 表达率 显著性 癌治疗 Breast Cancer Neoadjuvant chemotherapy CerbB - 2
分类号 R737.9 [医药卫生—肿瘤] R730.53 [医药卫生—肿瘤]
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参考文献7

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同被引文献25

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浙江临床医学
2006年 第1期

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