急性白血病合并严重血小板增多症

Acute leukemia complicated with severe thrombocytosis

目的探讨急性白血病合并严重血小板增多症的细胞遗传学特点及其临床和实验室特征。方法报告1例罕见的急性白血病合并严重血小板增多症病例的临床资料并结合相关文献进行分析。结果应用染色体常规G显带方法没有发现细胞遗传学异常,其他实验室特征包括外周血小板数达1 224×109/L,骨髓中原始细胞主要表达髓系细胞免疫标志,骨髓培养示巨核细胞集落形成单位高于正常对照并有空白自发集落生成。结论急性白血病与合并的血小板增多症可能有共同的发生机制,常规染色体检查结果阴性可能意味着染色体发生了更为复杂的改变,需用更先进的方法才能检出。

Objective To investigate the cytogenetic features as well as clinical and laboratory criteria of acute leukemia complicated with severe thrombocytosis. Methods Clinical data and relative literatures of a rare case of acute leukemia complicated with severe thrombocytosis were reported and analyzed. Results The cytogenetic foundings were normal by G banding. Other characteristics were included： the platelet count was 1224 × 10^9/L,blast cells in the bone marrow mainly expressed myelogenous markers, the increased colonies formation and the spontaneous colonies growth of megakaryocyte from bone marrow were found. Conclusion Acute leukemia may share the same pathogenesis with complicated thrombocytosis. The negative results of routine chromosome examination may indicate that the chromosomes may have undertaken more complex alterations,which need to be detected by advanced approaches.