医院感染产AmpC酶鲍氏不动杆菌的检测

Detection of Acinetobacter baumannii Producing AmpC Enzyme in Nosocomial Infection

目的探讨医院感染鲍氏不动杆菌产AmpC酶的分离情况、分布特征及耐药性。方法对医院感染42株鲍氏不动杆菌分布科室和感染部位分析,并用三维试验检测AmpC酶。结果42株鲍氏不动杆菌中产AmpC酶18株,产AmpC酶阳性率为42.86%;而非医院感染40株鲍氏不动杆菌中产AmpC酶6株,产AmpC酶阳性率为15.00%;医院感染鲍氏不动杆菌在临床科室的检出主要以烧伤科为主,而感染部位则是呼吸道和皮肤软组织两者共>90%;医院感染的鲍氏不动杆菌耐药性明显高于非医院感染。结论医院感染鲍氏不动杆菌产AmpC酶的分离率高,耐药率也较高,应针对它的易感因素,采取相应的措施,防止该菌引起的医院感染。

OBJECTIVE To explore the isolation, distributive characteristics and drug resistance of Acinetobacter baumannii producing AmpC enzyme in nosocomial infection. METHODS The distributive sections and infected parts of 42 A. baumannii strains in nosocomial infection were analyzed, and three dimensional test was used to detect AmpC enzyme. RESULTS Among them 18 （42.86 %） strains were AmpC positive. Among 40 strains of A. baumannii in non-nosocomial infection, 6 （15. 00%） strains were AmpC positive. A. baumannii in nosocomial infection in clinical sections was mainly discovered in burn department, and the respiratory tract and skin soft tis- sue were the main infected sites （90%）. The drug resistance in nosocomial infection was obviously higher than that of A. baumannii in non-nosocomial one. CONCLUSIONS The isolated rate and drug resistance rate of A. baumannii producing AmpC enzyme are rather high in nosocomial infection. It＇s neccessary to take measures to prevent the nosocomial infection caused by A. bauraannii.