3种常见肠杆菌科细菌耐药性变迁调查

Antibiotics Resistance Status Changing among 3 Kinds of Bacteria in Enterobacteriaceae

目的探讨本地区肺炎克雷伯菌、大肠埃希菌和阴沟肠杆菌的感染现状和耐药性变迁,为合理使用抗生素提供理论依据。方法用常规方法分离鉴定病原菌,用K-B法作体外耐药监测。结果3种常见肠杆菌科细菌中肺炎克雷伯菌分离率居首位,大肠埃希菌次之;5年中,3种菌对12种常用抗生素耐药率总体呈上升趋势,且产超广谱β-内酰胺酶(ESBLs)菌检出率由2000年16.5%上升到2004年32.4%,呈现上升趋势。结论临床应加强合理使用抗生素管理,控制耐药菌的产生和医院感染暴发流行。

OBJECTIVE To investigate the drug resistance status of Klebsiella pneumoniae, Escherichia coli and Enterobactercloacae for reasonable use of antibiotics. METHODS After genus identification, drug resistance profile was analyzed by K-B method. RESULTS The predominant isolates from Enterobacteriaceae were K. penumoniae and E. coli. The resistant rate of the three commonly encountered bacteria in Enterobacteriaceae to antibiotics ascended yearly, with increasing isolates harboring ESBLs from 16.5% （2000） to 32.4% （2004）. CONCLUSIONS Rational use of antibiotics should be obey the results of laboratory antibiotics susceptibility test to control the increasing trend and forbid outbreak of resistance.