微波辐射固体酸催化合成对羟基苯甲酸苄酯的研究

SYNTHESIS OF BENZYL p-HYDROXYBENZOATE USING SOLID ACID AS CATALYST UNDER MICROWAVE IRRADIATION

采用微波辐射技术,以对羟基苯甲酸和苄醇为原料,硫酸氢钠或硫酸锆为催化剂,合成了对羟基苯甲酸苄酯。最佳反应条件:微波辐射功率为464 W,辐射时间为4 min,醇酸摩尔比为5∶1,催化剂用量为0.2 g,酯化率分别为98.6%和97.5%。

Benzyl p-hydroxybenzoate was directly synthesized from p-hydroxybenzoic acid and benzyl alcohol using sodium bisulfate （A） or zirconium sulfate （B） as catalysts under microwave irradiation. The optimal reaction conditions were found as follows： microwave power 464 W, irradiation time 4 min, the molar ratio of alcohol to acid 5 ： 1. Under the optimal conditions, with 0.2 g sodium bisulfate or zirconium sulfate as catalysts, the yield was up to 98.6 % and 97.5 %, respectively. The experimental results showed that proper microwave irradiation could speed up the reaction of the esterification and high yield could be obtained.