A型肉毒毒素肌肉注射疗法在特发性眼睑、面肌痉挛中的应用

Effect of botulinus toxin type A on idiopathic blepharospasm and facial spasm

目的探讨A型肉毒毒素注射治疗特发性眼睑、面肌痉挛的疗效。方法应用A型肉毒毒素对按Cohen、Albert等分级为Ⅱ～Ⅳ级特发性眼睑、面肌痉挛的患者72例进行眼轮匝肌、口轮匝肌及面部肌肉多点注射治疗，对治疗前后的病情分级进行对比。结果应用A型肉毒毒素治疗特发性眼睑、面肌痉挛的短期有效率为97．2％，丰年的复发率为58．3％，未见过敏反应及严重全身不良反应。结论A型肉毒毒素为治疗特发性眼睑、面肌痉挛首选药物，尽管其疗效半年左右，但仍不失为一种简单有效的治疗方法。

Objective To research the effect of botulinus toxin type A on idiopathic blepharospasm and facial spasm. Methods 72 patients of idiopathic blepharospasm and facial spasm were divided into different grades between Ⅱ - Ⅳaccording to Cohen and Albert,were treated with botulinus toxin Type A injection treatment on many- points including orbicularis oculi, orbieularis oris. and facial muscles, classify the state of illness before and after the treatment,and then analyze the treatment result. Results The short - term effect of the botulinus toxin Type A injection treatment to blepharospasm and facial spasm was 92.7 %, the half- year relapse rate was 58.3 %, and there was no anaphylactic response or serious systemic adverse reaction. Conclusion Botulinus toxin Type A is the first choice in treating blepharospasm and facial spasm ,although its curative effect last for half a year,it is still a simple and effective treatment method.