生长抑素对肝癌术后血浆内血管内皮生长因子和转化生长因子-β1水平影响的研究

The effect of somatostatin on the levels of plasma vascular endothelial growth factor and transforming growth factor beta1 after hepatectomy in hepatocellular carcinoma patients

目的研究肝癌肝切除后血浆血管内皮生长因子（VEGF）和转化生长因子-β（TGF-β）的变化，与生长抑素（SST）对肝切除后血浆VEGF和TGF-β变化的影响。方法将2002-2003年拟行手术治疗的20例肝癌病人随机分为治疗组与对照组，每组各10例，用双抗体夹心ELISA方法检测病人手术前后血浆VEGF和TGF-β的浓度变化。结果对照组术后血浆VEGF与TGF-β浓度较术前明显增高（P〈0．05）。SST治疗组术后血浆VEGF与TGF-β浓度较对照组术后明显降低（P〈0．05）。结论应用SST能明显降低血浆VEGF与TGF-β的浓度，VEGF与TGF-β促残瘤生长的作用可能受到抑制，提示SST对于预防肝癌手术后残瘤的复发可能有作用。

Objective To investigate the effect of somatostatin （SST） on the levels of plasma vascular endothelial growth factor （VEGF） and transforming growth factor betal （TGF-β1） after hepatectomy in hepatocellular carcinoma patients. Methods From March 2002 to April 2003,20 patients after hepatectomy were randomly divided into two groups, SST treatment group （10 cases） and control group （10 cases）. The plasma levels of VEGF and TGF-β1 were measured by Elisa method. Results The plasma levels of VEGF and TGF-β1 after hepatectomy in control group were significantly increased than that before operation, P 〈 0.05. The plasma levels of VEGF and TGF-β1 after hepatectomy in SST treatment group was significandy decreased than that in control group, P 〈 0. 05. Conclusion The administration of SST after hepatectomy could significantly decreased the plasma levels of VEGF and TGF-β1. The effect of enhancing growth of residual tumor tissue by VEGF and TGF-β1 might be suppressed. The result showed that the administration of SST might be beneficial to prevent the recurrence of residual tumor after surgery.