鼻咽癌患者和正常人尿液中的亚硝胺水平

Volatile Nitrosamines Levels in Urine of NPC Patients and Normal Persons

作者采用气相色谱－热能分析法，测定了７０份鼻咽癌患者和正常人尿样中的挥发性亚硝胺水平。两组尿样中的二甲基亚硝胺水平分别为０．５５±０．４０μｇ／Ｌ、０．４５±０．３４μｇ／Ｌ，两者比较无显著性差异（Ｐ＞０．０５）；二乙基亚硝胺水平分别为０．２２±０．２０μｇ／Ｌ、０．３２±０．２６μｇ／Ｌ，两者比较亦无显著性差异（Ｐ＞０．０５）。然而，鼻咽癌患者尿样中的亚硝胺阳性检出率高达６２．９％，正常人为５４．３％，提示鼻咽癌的发生与当地居民的饮食因素和内源性亚硝胺形成有关。

The levels of nitrosamine in 70 utine samples of nasopharyngeal carcinom (NPC)patients and normal persons were determined,using GC-TEA method. The levels of dimethylnitrosamine (DMNA)in the samples of the two groups were 0.55±0.40 μg/L,0.45±0. 34μg/L,respectively.No difference was significant,comparing both levels of DMNA(P>0.05).The levels of diethylnitrosamine (DENA) in the samples of two groups were 0.22±0. 20 μg/L,0.32±0.26 μg/L,respectively. No difference was significant, too,comparing both levels of DENA(P>0. 05). However, the positive detection rate of nitrosamines was high up to 62.9%in urine samples of NPC patients,54.3%in urine samples of normal persons,It suggested that occurrence of NPC is probably associated with the diet factors of local residents and the endogenous formation of nitrosamines.