多途径综合治疗原发性巨块型肝癌48例疗效分析

Effects of Comprehensive Treatment in Multiple Ways for 48 Cases of Primary Massive Liver Cancer

作者对４８例不能一期切除的原发性巨块型肝癌进行多途径的综合治疗。在一期探查术中应用肝动脉结扎、碘化油化疗药物（ＭＤＦ）混合液灌注化疗和液态硅胶（ＴＨ）栓塞术；术后行肝动脉、门静脉分期灌注化疗；化疗间期经皮向癌灶内分点注射无水酒精。综合治疗半年复查结果：ＰＲ６６．７％、ＭＲ２２．９％、ＳＤ１０．４％。复查后依据病情施行Ⅱ期手术切除２３例，占本组病例的４７．９％（２３／４８）。本组病例随访结果：６、８、１０个月、１、３、５年生存率分别为９３．８％、８７．５％、７９．２％、７５．０％、５６．１％、２５．９％。结果显示，多途径综合治疗疗效显著。

cases of primary massive liver cancer , which can not be performed first resection,were treated by the combination of the hepatic artery ligation, perfusion chemotherapy with Lipiodol and chemotherapeutic drug (M.D.F),embolism of TH, perfusion chemotherapy by stages through hepatic artery and portal vein after operation, and the injection of anhydrous alcohol in the foci during the interval of chemotherapy. The responses to the treatment after 6 months were PR66.7%,MR22.9%, SD 10.4%. According to the state of the disease after reexamimation, secondary operation was performed in 23 cases, accouting for 47.9%of all cases.The follow-up survey demonstrated that the survival rates of 6 month,8 month,10 month,1 year, 3 year, 5 year were 93.8%, 87.5%,79.2%, 75.0%, 56.1%,25.9%,respectively.The results suggested that the comprehensive treatment in multiple ways had better therapeutic effect on primary massive liver cancer