利用INTERNET进行蛋白质结构的检索、图像显示和模型构建

Retrieval and display of protein structure and protein modeling on the INTERNET

越来越多的蛋白质结构数据库和软件资源可以通过ＩＮＴＥＲＮＥＴ的ＷＷＷＭｏｓａｉｃ和Ｎｅｔｓｃａｐｅ程序存取。利用ＰＤＢ－Ｂｒｏｗｓｅ可以对ＰｒｏｔｅｉｎＤａｔａＢａｎｋ进行各种灵活的检索。ＳＣＯＰ是蛋白质结构分类数据库，它根据蛋白质的家族和折叠来分层次地组织蛋白质结构数据，当某一个感兴趣的蛋白质被检出后，很容易地发现结构与之相似的蛋白质。ＲＡＳＭＯＬ是生物大分子图像显示软件，可以对蛋白质结构图形进行各种操作。ＤＡＬＩ服务器可以将一个蛋白质的结构与所有已知的结构进行比较，检出具有类似结构的蛋白质。Ｓｗｉｓｓ－Ｍｏｄｅｌ通过蛋白质的氨基酸序列预测其结构和构建蛋白质的模型。

There is now a rapidly expanding population of interlinked protein structure databases and softwares on the World Wide Web that can be readily accessed from a desk top PC using programs such as NCSA Mosaic or Netscape. The PDB Browse software provides various search methods for Protein Data Bank (PDB) entries. SCOP, a structural classification of proteins data base, organizes proteins hierarchically according to their families and folds. Once the protein of interest has been identified, it is easy to find other proteins of similar structure. RASMOL views and manipulates 3D structures of biomolecules in various ways. The DALI server performs protein structure comparison and database search with a new structure against all structures in the PDB. Using Swiss Model, an automated protein modeling server, protein structures can be derived from their sequences and protein modeling can be performed by e mail.