胰岛素依赖型糖尿病肾病患者红细胞膜钠锂交换活性测定及意义

Determinationofsodium┐lithiumcountertransportactivityinredbloodcelsofIDDMpatientswithnephropathy

探讨红细胞膜钠锂交换活性（ＳＬＣＡ）与胰岛素依赖型糖尿病（ＩＤＤＭ）肾病之间的关系。方法采用Ｃａｎｅｓｓａ建立的方法，测定了１３例ＩＤＤＭ肾病，以及性别、年龄、糖尿病病程和体重指数（ＢＭＩ）等匹配的１２例正常白蛋白尿ＩＤＤＭ患者红细胞膜ＳＬＣＡ。结果ＩＤＤＭ肾病红细胞膜ＳＬＣＡ０．４６（０．３７～０．５４）ｍｍｏｌ·Ｌ－１·ＲＢＣ－１／ｈ显著高于正常白蛋白尿ＩＤＤＭ患者ＳＬＣＡ０．３０（０．２１～０．３９）ｍｍｏｌ·Ｌ－１·ＲＢＣ－１／ｈ（Ｐ＜０．００１）。

bjectiveToclarifytherelationshipbetweensodium-lithiumcountertransportactivity(SLCA)andIDDMnephropathy.Methods13IDDMpatientswithdiabeticnephropathywerecomparedwithagroupof12IDDMpa-tientswithoutmicroalbuminuria,thelatergroupwasmatchedinrespectofsexdistribution、age、durationofdia-betesandbody-Massindex(BMI).SLCAinredbloodcelsofalpatientsweredeterminedbyCanessamethods.ResultsRedcelSLCAwassignificantlyhigherinthediabeticnephropathygroup0.46(0.37～0.54)mmol·L-1·RBC-1/hthaninthenon-nephropathygroup0.30(0.21～0.39)mmol·L-1·RBC-1/h(P<0.001).Conclu┐sionSLCAmaybeapotentialyusefulearlymarkerofIDDMnephropathy.