锰作业工人免疫球蛋白和微量元素含量变化

Analysis on contents of immunoglobulin and microelements in manganese exposure workers

目的探讨锰作业工人长期接触锰烟尘对机体免疫功能和微量元素含量的影响变化。方法采用单向免疫扩散法和原子吸收分光光度计分别测定116名锰作业工人血清免疫球蛋白(IgA、IgG、IgM)含量和血中锰、锌、铜、铁和尿锰的含量。结果锰作业工人血清IgG、IgM均低于对照组(P<0.05);锰作业工人血清IgM、IgG与血锰含量呈负相关;尿锰与血锰含量呈正相关(P<0.05),当血锰0.05μmol/L以上时,血锌、铜出现不同程度的下降,血铁含量变化不明显。结论锰作业工人长期接触锰烟尘,能降低机体微量元素锌、铜含量,并对免疫功能存在不同程度的抑制作用。

Objective To study the effects of long-term manganese fumes exposure on changing content of immune function and microelements in workers. Methods Immunodiffusion method and atomic absorption spectrophotometer method were used to examine the content of the serum immunoglobulin （IgA, IgG, IgM） and microelements （Zn, Cu, Fe, Mn） in blood and manganese in the urine of 116 people with manganese fumes exposure. Results The content of serum IgG, IgM on the manganese-contact group was lower than that of the control group. The IgM and IgG had a highly netgative relation with the blood manganese content （P 〈 0.05 ）. When the blood manganese concentration was 0.05μmol/L, the blood zinc and cuprum was lower （P 〈 0.05）. Conclusion Manganese has a restrictive effect on the microelements （Zn, Cu） and immunity function in manganese exposure workers.