三氯乙烯对职业接触人群脂质过氧化作用

Lipid peroxidation effects of trichloroethylene on occupationally exposed wokers

目的探讨三氯乙烯(trichloroethylene,TCE)对职业接触人群外周血脂质过氧化作用的影响。方法采集207名直接接触TCE工人的班末尿和外周肘静脉血,分析尿中三氯乙烯(Trichloroactic acid,TCA)含量,测定外周血过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、丙二醛(MDA)的活性或含量。结果接触组工人红细胞CAT、血清总SOD和GSH-PX活性以及血清中脂质过氧化产物MDA含量均呈现升高趋势,CAT、总SOD与接触TCE的工龄,以及CAT、总SOD、GSH-PX与接触剂量间均呈显著的抛物线性关系,MDA与接触工龄及接触剂量间均呈直线关系。结论TCE可引起职业接触人群脂质过氧化水平增高。脂质过氧化指标可作为早期职业接触损伤的生物效应指标之一。CAT可作为早期、敏感的生物效应监测指标。

Objective To evaluate the lipid peroxidation effects of trichloroethylene （TCE） on occupationally exposed individuals. Methods 207 pieces of shift-ending urine and blood from occupationaly exposed workers were collected. To analyse the level of urine Trichloroactic acid （TCA） and lipid peroxidation in peripheral blood such as the activity or concentration of calalase （CAT） superoxide dismutase （SOD） glutathione peroxidase （GSH-PX） and malondialdehyde （MDA） in various dosed groups. Results The activity of erythrocyte CAT, total serum SOD and GSH-PX or the coneetration of serum MDA significantly increased compared with the controls. CAT, total SOD was assumed to have parbaolical correlation with the exposure time, CAT, total SOD and GSH-PX had the same corelation with urine TCA concentration. MDA had significant linear correlation with the exposure time or urine TCA concentration. Conclusion TCE can stimulate lipid peroxisome proliferation. The lipid peroxidation level of the peripherl blood may be one of the early biomarkers of TCE exposure. CAT may be applied as one of the early and secsitive bio-effect indexs.