自由基酰化反应合成4-氯-2,6-二酰基吡啶

Synthesis of 4-chloro-2,6-diacylpyridines through free radical substitutions

由4-氯吡啶通过自由基酰化反应合成4-氯-2,6-二乙酰基吡啶和4-氯-2,6-二丙酰基吡啶,方法简单,产率较文献方法高,分别达到25.7%和51.7%。

Starting from 4-chloropyridine, the target molecules, 4-chloro-2,6-diacetylpyridine and 4-chloro-2,6.dipropionylpyridine were synthesized through the radical acylation with a yield of 25.7% and 51.7%, respectively. The one-step synthetic method for the target molecule was a simpler way with higher yield comparing with the reported method.