女性高血压患者血清瘦素与胰岛素抵抗及左室肥厚的关系

Correlation between the serum concentration of leptin in femal patients with essential hypertension and insulin resistance and left ventricle mass

目的:探讨女性患者血清瘦素水平与胰岛素抵抗和原发性高血压左室肥厚的关系。方法:女性原发性高血压患者44例,对照组43例,测定其空腹血清瘦素、血糖、胰岛素、血脂、体重指数,稳态模型评估法计算胰岛素抵抗指数,心脏彩色多谱勒测定室间隔厚度并计算左心室重量指数,分析血清瘦素水平与胰岛素抵抗和原发性高血压患者左室肥厚的关系。结果:女性高血压组的血清瘦素水平、胰岛素抵抗指数高于对照组,差异有统计学意义(P<0.05),瘦素与胰岛素抵抗指数、左心室重量指数呈正相关。结论:女性高血压患者血清瘦素水平与胰岛素抵抗和左室肥厚有关。

Objective To explore the serum concentration of leptin and the correlation between insulin resistance, left ventricle mass in female patients with essential hypertension. Methods Fortyfour cases of female essential hypertension and 43 cases of healthy subjects （control group） were measured their fast serum leptin, blood sugar, insulin, serum lipids, and body mass index. Insulin sensitivity was assessed with the Homeostasis Model Assessment Insulin Resistance index （HOMAIR）. All subjects were detected with colour Doppler for determining the left ventricular mass. The correlation between left ventricle mass in the patients with essential hypertension and the serum concentration of leptin was explored. Results The leptin in the hypertension group was significantly higher than that in control group （P〈0. 05）, leptin correlated positively with HOMA-IR, sex, triglyceride, waist-hip ratio, body mass index, systolic pressure, and left ventricular mass. Conclusion Leptin is correlated with insulin resistance, left entricle mass in female patients with essential hypertension.