甲基莲心碱对电解性氧自由基损伤离体大鼠心脏的保护作用

Protective effect of neferine on electrolysis-induced oxygen free radicals injury in isolated rat heart

甲基莲心碱（Ｎｅｆ）显著降低电解性氧自由基损伤离体大鼠心脏所致室性心律失常发生率，减少心肌细胞中乳酸脱氢酶的释放及丙二醛的生成．对氧自由基所致的冠脉流量减少，左室内压（ＬＶＰ）及±ｄＰ／ｄｔｍａｘ的降低亦具有对抗作用。我们推测甲基莲心碱对电解性氧自由基损伤离体大鼠心脏的保护作用可能与其清除活性氧自由基及抑制脂质过氧化作用有关。

Neferine significantly decreased the incidence of ventricular arrhythmias induced by electrolysis-produced oxygen free radicals in the isloated rat heart.It dose-dependently reduced the release of LDH and the content of MDA in the myocardial cells,and also protected aganist the attenuation of coronary flow(CF),left ventricular pressure(LVP),positive and negatitve dP/dtmax(±dP/dtmax).These results suggest that the protective effect of neferine on electrolysis-induced oxygen free radicals injured heart is probably related to inhibiting lipid peroxide and scavenge oxygen free radicals.