摘要
在大鼠ｓｃ异丙肾上腺素（Ｉｓｏ）４０ｍｇ·ｋｓ－１·ｄ－１造成的心肌损伤模型上，观察外源性金属硫蛋白（ＭＴ）和锌诱导内源性ＭＴ对心脏的保护作用．结果发现：外源性和内源性ＭＴ均可减少Ｉｓｏ引起的心肌丙二醛和心肌组织钙的聚集，同时发现内源性ＭＴ可减少血浆组织蛋白酶Ｄ的活性。提示：ＭＴ保护Ｉｓｏ心肌损伤的机制可能与其清除自由基、抗脂质过氧化、减少细胞内钙超载、稳定溶酶体膜等作用有关。
The protective roles of metallothionein on isoproterenol-induced myocardial injury were investigated by using exogenous administered MT and peinjected Zn-induced MT in rats.The results showed that both exogenous and induced MT decreased cardiac malondinldehyde levels and myocardial calcium contracentions and induced MT decreased plasma cathepsin-D activities in the rats of isoproterenol-induced myocardial injury.These data suggested that mechanisms which MTs play a role in rats d isoproterenol-induced myocardial injury may be related with that MTs act as a free radical scavenger,inhibit cell membrance lipid peroxidation,maintain the stabilities of intracellular calcium and lysosome membrane.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1996年第4期332-334,共3页
Chinese Pharmacological Bulletin
