枸橼酸乙胺嗪对离体豚鼠胸主动脉环的影响

Effects of diethylcarbamazine citrate on isolated thoracic aortic ring of guinea-pig

本工作观察了抗丝虫药枸橼酸乙胺嗪（ＤＥＣ）对离体豚鼠胸主动脉环收缩功能的影响。结果显示，ＤＥＣ能显著抑制ＫＣｌ和去甲肾上腺素（ＮＥ）引起的胸主动脉环收缩．使ＫＣｌ和ＮＥ引起的动脉环收缩的剂量效应曲线右移，最大效应降低，均表现为非竞争性拮抗，其ｐＤ＇２值分别为１．９９１和２．２７１。对收缩机制影响研究发现，ＤＥＣ对细胞内Ｃａ２＋释放和外Ｃａ２＋内流均有明显抑制作用。提示ＤＥＣ可能通过其钙拮抗作用影响血管的收缩。

This work studied the effects of diethylcarbamazine citrate (DEC) on the contraction of isolated thoracic aortic ring of guinea-pig.DEC could markedly inhibit the contraction of thoracic aortic rings induced by KCl and norepinephrine(NE) in a concentration-dependent manner,shifted the cumulative dose-response curves of KCl and NE to right,and reduced the maximal efficacy of contraction in a nonCompetitive antagonistic manner.The pD'2 values of KCl and NE were 1.991 and 2.271 respectively.The further studies of contractive mechanism indicated that DEC inhibited both the Ca2+ release from intracellar storage sites and the influx of extracellar calcium significantly.These results suggest that DEC inhibits vascular contraction through its calcium-antagonistic effect.