醋氨己酸锌对半胱胺大鼠溃疡模型的影响

Effect of zinc acexamate on healing of cysteamine induced duodenal ulcers in rats

用半胱胺在大鼠上引起非弥散性和弥散性十二指肠溃疡，并以雷尼替丁作为对照，研究了醋氨己酸锌对溃疡的预防作用和治疗作用。弥散性十二指肠溃疡有一个较长的愈合过程，在用醋氨己酸锌治疗５０ｄ后，溃疡受到极明显的抑制。对非弥散性十二指肠溃疡也表现了极好的预防作用。另外，对醋氨己酸锌各个剂量溃疡愈合的形态学也进行了比较，发现在不同的剂量时显示不同的损伤修复及愈合情况，明显地加速了受损处的上皮细胞、十二指肠腺及平滑肌细胞的增殖。

The effect of ulcer-preventing and treatment on ulcer healing of zinc acexamate(ZAC)on cysteamine-induced nonpentrating and penetrating duodenal ulcers(DU) in rats was investigated through ranitidine as comparison.Penetrating DV in rats have a very prolonged course of healing.After 50 days of treatment with ZAC,the ulcers was inhibited markedly.And an execlent ulcer-preventing effect on nonpenetrating DU was shown.In addition,the morphology of healing ulcers in different ZAC group was also compared.The proliferation damaged epithelium,Brunner's glands and smooth muscle cell was accelerated obviously by ZAC.