摘要
哌嗪乙氧基雌酮是一种可望用于防治骨质疏松症的全新合成的雌激素类化合物,本文采用EI-MS、FAB(-)-MS、ESI-MS三种质谱技术分别对其结构和裂解途径进行了研究。采用FAB(-)-MS,获得m/z404[M+Na-H]-、382[M]-、381[M-H]-质谱峰;采用EI-MS,获得m/z382 M+.;采用ESI-MS,获得m/z383[M+H]+。分子离子m/z382 M+.和主要特征子离子与其结构特征相符,并解释了其中的主要特征子离子,对其结构和裂解途径进行了确证。
Piperazinylethylestrone is a new syntnenc compound that cam be ised fpr tje prevention and treatment of osteoporosis and other diseases caused by osteoporosis. Electron ionization mass spectrometry (EI-MS) and fast atom bombardment mass spectrometry (FAB (-) -MS) were used for the elucidations of its structure and fragmentation pathway. The ion peaks m/z 404[M+Na-H]^-, 382[M]^-, 381[M-H]^- were detected by FAB(-)- MS; m/z 382 M^+ was detected by EI-MS; m/z 383[M+H]^+ was detected by ESI-MS and the molecular formula of piperazinylethylestrone could be assigned as C24 H34 N2 O2. Furthermore, the fragmentation pathway of piperazinylethylestrone was also explained.
出处
《质谱学报》
EI
CAS
CSCD
2006年第1期30-32,36,共4页
Journal of Chinese Mass Spectrometry Society
基金
国家自然科学基金重点资助项目(防治老年骨质疏松症新型药物的研究No.39430120)的子课题