3种抗肿瘤药物联用于氯化钠注射液中的配伍稳定性

Compatibility and stability of three anti-cancer drugs in sodium chloride injection

目的模拟非霍奇金淋巴瘤化疗EPOCH方案中依托泊苷、吡喃阿霉素、长春新碱3种抗肿瘤药物临床联用的浓度,评价混合配置于NS注射液中的配伍稳定性。方法按所需浓度配置测试样本,于0、2、4、8、122、4 h观察物理稳定性及HPLC法测定药物组分含量变化。结果各组分药物在24 h内外观、pH、药物组分均稳定。结论上述3种抗肿瘤药物混合配置于NS注射液中,于25℃2、4 h内理化性质稳定,可配伍联用于肿瘤化疗患者24 h的持续静脉滴注。

AIM To evaluate the physical compatibility and chemical stability of the admixture of etoposide , pirarubicin, and vincristine , and to decide the concentrations of three drugs by the clinical application dose in 0.9 % sodium chloride injection. METHODS The test samples were prepared in non-PVC bags of the infusion solution at the required drug concentrations. Evaluations were performed initially and in 0, 2 , 4 , 8, 12 , 24 h for physical and chemical stability. Physical stability was assessed by using visual observation in normal fluorescent light . Chemical stability of three drugs was evaluated by using HPLC analytic techniques. RESULTS All samples were physical and chemical stable in 24 h. CONCLUSION Admixtures of etoposide , pirarubicin, and vincristine are physically and chemically stable in 24h at 25 ℃.