50例小儿细菌性肠炎病原菌及药敏分析

Analysis of pathogenic bacterium and antimicrobial susceptibility of 50 cases in child bacterial enteritis

目的:分析小儿细菌性肠炎病原菌及其耐药情况,以指导临床合理用药。方法:对306例细菌性肠炎患儿的标本进行粪便培养,其中阳性50例做药物敏感试验。结果:50例阳性病例,致病菌占52%,条件致病菌占16%,菌群失调占32%。氨苄西林、阿莫西林-克拉维酸、复方新诺明敏感率较低,分别为56.00%、66.67%、63.64%,三代头孢、氨基糖苷类、喹诺酮类敏感率较高。结论:三代头孢可作为小儿细菌性肠炎首选用药,>6岁患儿,可考虑选用氨基糖苷类或喹诺酮类。

Objective： To analyze the distribution of the pathogen in child bacterial enteritis and its resistance to antibiotics, and establish guidelines for rational use of antibiotic. Methods： Culture of feces was performed in 306 cases of bacterial enteritis, 50 of which were discovered positive and tested for antibiotic susceptibility. Results： The bacterium of these 50 cases consisted of 50% disease-causing germs （50%）, chance-disease-causing germs （16%） and the lost-balance in intestinal bacterium （32%）. The sensitivity rates of aminopenicillin, amoxicillin-clavulanic acid, SMZ-TMP were low, which were 56.00%, 66.67%, 63.64% in turm, The sensitivity rates to the third generation cephalusporins, amino glycosides, quinolones were higher. Conclusions： Considering the limitation of the medicine for child bacterial enteritis, the third generation cephalosporins could be chosen first, For the children ahove 6-year-old , amino glycosides could be used. When all these are not effective enough , quinolones could be used.