交沙霉素在毛细支气管炎中的应用

The therapeutic effects of josamycin propionate granules on infant with bronchiolitis

目的:探讨交沙霉素治疗毛细支气管炎的疗效及其作用机制。方法:将60例确诊为毛细支气管炎的患儿随机分为常规治疗组和交沙霉素治疗组,评价其治疗效果,并用ELISA法检测患儿的血清IL-13水平,免疫荧光法测CD4+、CD8+及计算出CD4+/CD8+比值。结果:交沙霉素治疗组与常规治疗组相比,疗效更好,并能使患儿外周血TH2细胞的过度活化和TH2类因子的偏移状态得到纠正,CD4+/CD8+比值下降。结论:治疗毛细支气管炎除使用传统的常规治疗方法以外,加用交沙霉素可获得更好的疗效,同时可调节患儿失调的免疫状态。

Objective： To explore the therapeutic effects and mechanism of action of josamycin propionate granules on infants with bronchiolitis. Methods： 60 infants who suffered from bronehiolitis were divided into two groups： the control group with traditional treatment aud the treatment group with josamyein propionate granules, with their therapeutic effects evaluated. The infants＇ scrum IL-13 was detected by the method of ELISA and CD4^＋, CD8^＋ by immunofluorescence, and the value of CD4^＋/CD8^＋ was calculated. Results： Compared with the control group, the treatment group is better in the therapeutic effects, and excessive activation and exeursion of TH2 cell in the infant＇s peripheral blood could be rectified. The value of CD4^＋CD8^＋ decreased. Conclusions： Traditional treatment with josamycin has better therapeutic effects and accommodates the infant＇s disturbed immune state.