聚(丙交酯-co-乙交酯)/β-磷酸三钙复合物的电纺研究

ELECTROSPINNING OF POLY(LACTIDE-co-GLYCOLIDE)/β-TRICALCIUM PHOSPHATE COMPOSITES

对生物可吸收聚(丙交酯-co-乙交酯)(poly(lactide-co-glycolide),PLGA)与β-磷酸三钙(-βTCP)复合物体系进行了电纺.研究了PLGA的浓度,-βTCP与PLGA比例,加料速度,电压,喷头与接收体之间的距离等因素对电纺过程的影响,制备出纳米纤维膜,并用扫描电镜(SEM)等对纤维膜进行表征.结果表明,电纺溶液浓度越高,或者加料速度越快,纳米纤维的直径越粗.力学实验显示,复合物中-βTCP的含量增加使纳米纤维膜的拉伸强度和杨氏模量下降.

The Bioresorbable nanofiber mats of （PLGA/β-TCP） were electrospun. The effects of the poly（lactide-co-glycolide）/β-tricalcium phosphate composites most important processing parameters including PLGA solution concentration, β-TCP/PLGA weight ratio, feed rate, voltage, and distance between the tip and the receiver on the composite nanofiber mats were investigated in detail. Then, the composite nanofiber mats were characterized by scanning electron microscopy （SEM）, TEM （transmission electron microscopy） and tensile tester. The SEM images showed that the diameters of PLGA/β-TCP nanofibers were increased with the increasing of the concentration of PLGA and feed rate. The results of tensile tests revealed that the tensile strength and Young＇ s modulus of the composite nanofiber mats were lowered with increasing the content of β-TCP.