POEMS综合征15例临床分析

Clinical analysis of 15 patients with POEMS syndrome

目的探讨POEMS综合征的临床特征。方法对15例POEMS综合征患者临床资料、相关检查及治疗方法进行回顾性研究。结果15例患者均有多发性神经病、淋巴结肿大、水肿、异常球蛋白血症及皮肤色素沉着,其他症状包括肝肿大6例、脾肿大9例、性功能障碍12例等。患者均予激素治疗,其中6例合用人血免疫球蛋白静滴。结论PO-EMS综合征是一种少见的多脏器损害疾病,诊断较难。临床上对可疑病例需进行密切观察及必要的检查,以免误诊。

Objective：To evaluate the clinical features of POEMS syndrome. Methods： The clinical materials of 15 pa tients with POEMS syndrome were analysed retrospectively. Results： All 15 patients presented polyneuropathy, enlargement of I.ymph Nodes, edema, abnormal globulinemia and hyperpigmented skin. 6 patients were complicated with hepatomegaly, 9 cases with splenomegalia and 12 cases with impotence. All were treated with corticoid, 6 with human immunoglobulin. Conclusions： POEMS syndrome was a rare disease with multiorgan involvement which made its diagnosis difficult. So suspected cases should be given close observation and taken necessary examination to avoid misdiagnosis.