期刊文献+

鼻咽清毒颗粒合用鼻渊舒口服液治疗放疗后鼻咽癌患者的临床研究 被引量:4

Clinical Study of Bi Yan Qing Du Granule and Bi Yuan Shu Oral Liquid in Treatment Patients with Nasopharyngeal Carcinoma after Radiotherapy
下载PDF
导出
摘要 [目的]观察鼻咽清毒颗粒合用鼻渊舒口服液对鼻咽癌患者放疗后EB病毒壳抗原抗体VCA/IgA滴度水平和鼻咽部症状的作用。[方法]将62例鼻咽癌放疗后患者按就诊时间顺序分成实验组(鼻咽清毒颗粒联合鼻渊舒口服液组)32例和对照组(鼻咽清毒颗粒组)30例。[结果]实验组和对照组治疗前EB病毒VCA/IgA几何平均滴度分别为1∶86.68和1∶70.63(P>0.05)。治疗后实验组VCA/IgA几何平均滴度为1∶28.07;对照组VCA/IgA几何平均滴度为1∶53.90(P<0.05)。实验组治疗后对于鼻咽部脓性分泌物的症状改善情况好于对照组。[结论]鼻咽清毒颗粒合用鼻渊舒口服液对鼻咽癌患者放疗后EB病毒VCA/IgA滴度水平有明显的抑制作用,对其鼻咽部症状有较好的改善作用。 [Purpose]To investigate the effect of Bi Yan Qing Du granule combined with Bi Yuan Shu oral liquid on the titers of EB virus VCA/IgA and on nasopharyngeal symptoms in patients with nasopharyngeal carcinoma (NPC) after radiotherapy. [Methods]Sity-two NPC patients after-radiotherapy were randomly divided into study group (Bi Yan Qing Du granule combined with Bi Yuan Shu oral liquid group,n=32) and control group(Bi Yan Qing Du granule group,n=30) based on the clinical sequence.[Results] The geometric mean titer(GMT) of VCA/IgA was 1:86.68 in study group and 1:70.63 in control group before treatment(P〉0.05). The GMT of VCA/IgA was 1:28.07 in study group, and 1:53.90 in control group after treatment (P〈0.05). The nasopharyngeal pus was significantly reduced in study group than that in control group(P〈0.05).[Conclusion] The application of Bi Yan Qing Du ganule combined with Bi Yuan Shu oral liquid can significantly decrease the titers of VCA/IgA in NPC patients after-radiotherapy and improve the nasopharyngeal symptoms.
出处 《中国肿瘤》 CAS 2006年第2期113-115,共3页 China Cancer
基金 国家杰出青年科学基金资助(No.39925035)
关键词 鼻咽肿瘤 EB病毒 VCA/IGA nasopharyngeal neoplasms EB virus VCA/IgA
  • 相关文献

参考文献10

  • 1Pickard A,Chen CJ,Diehl SR, et al. Epstein-Barr virus seroreactivity among unaffected individuals within highrisk nasopharyngeal carcinoma families in Taiwan[J]. Int J Cancer, 2004, 111(5): 117-123.
  • 2Henle W, Ho JHC, Henle G, et al. Nasopharyngeal carcinoma: significance of change in Epstein-Barr virus-related antibody patterns following therapy[J]. Int J Cancer, 1977,20 (5): 663-672.
  • 3Fachiroh J,Schouten T, Hariwiyanto B, et al. Molecular diversity of Epstein-Barr virus IgG and IgA antibody responses in nasopharyngeal carcinoma: a comparison of Indonesian, Chinese, and European subjects[J]. J Infect Dis, 2004, 190 (1):53-62.
  • 4季明芳,郭媛卿,梁锦胜,郑受昂,程伟民,余炳辉,欧星泰,王得坤.鼻咽癌患者发病前后EB病毒VCA/IgA和EA/IgA滴度动态分析[J].中华肿瘤杂志,2003,25(3):243-245. 被引量:30
  • 5钟建明,曾毅,廖建,李秉钧,潘文俊,严壮南,韦继能,王培中,黎而介.Epstein-Barr病毒IgA/VCA抗体变动规律和鼻咽癌发病的关系[J].中华实验和临床病毒学杂志,1996,10(3):225-228. 被引量:19
  • 6Shao JY, Li YH, Gao HY, et al. Comparison of plasma Epstein-Barr virus (EBV) DNA levels and serum EBV immunoglobulin A/virus capsid antigen antibody titers in patients with nasopharyngeal carcinoma[J].Cancer, 2004 ,100(6):1162-1170.
  • 7Dolcetti R, Menezes J. Epstein-Barr virus and undifferentiated nasopharyngeal carcinoma: new irtimunobiological and molecular insights on a long-standing etiopathogenic association[J]. Adv Cancer Res, 2003, 87: 127-157.
  • 8Sam CK, Abu-Samah AJ, Prassad U. IgA/VCA as a followup marker the monitoring of nasopharyngeal carcinoma[J].Eur J Surg Oncol, 1994, 20 (4): 561-564.
  • 9刘宗潮 简少文 等.鼻咽清毒剂对EB病毒抗原表达抑制作用和细胞毒作用的研究[J].中草药,1999,30:158-159.
  • 10刘宗潮,简少文,李华忠,欧景才,谢冰芬,李端,冯公侃.抗EB病毒口服液对EB病毒抗原表达的抑制作用及其细胞毒作用[J].中草药,2004,35(5):542-545. 被引量:12

二级参考文献16

  • 1刘育希,中华肿瘤杂志,1979年,1卷,8期
  • 2曾毅,中华肿瘤杂志,1979年,1卷,2页
  • 3邓洪,病毒学报,1992年,8卷,32页
  • 4曾毅,中华耳鼻咽喉科杂志,1987年,22卷,145页
  • 5曾毅,肿瘤防治研究,1983年,10卷,23页
  • 6李振权,中华肿瘤杂志,1979年,1卷,250页
  • 7Wolf H, zur Hausen H, Becker V. EB viral genomes in epithelial nasopharyngeal carcinoma cell. Nat New Biol,1973, 244: 245-247.
  • 8Zong YS, Sham JS, Ng MH, et al. Immunoglobulin A against viral capsid antigen of Epstein-Barr virus and indirect mirror examination of the nasopharynx in the detection of asymptomatic nasopharyngeal carcinoma. Cancer, 1992,69: 3-7.
  • 9Sham JS, Wei WI, Zong YS, et al. Detection of subclinical nasopharyngeal carcinoma by fibreoptic endoscopy and multiple biopsy. Lancet, 1990, 335:371-374.
  • 10Sixbey JW, Yao QY. Immunoglobulin A-induced shift of Epstin-Barr virus tissue tropism. Science, 1992,255:1578-1580.

共引文献58

同被引文献104

引证文献4

二级引证文献36

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部