氟康唑胶囊联合大蒜素注射液治疗慢性乙型重型肝炎合并真菌感染的疗效分析

Analysis of curative effect on treating with fluconazole capsule and galic injection for patients of chronic severe hepatitis B with fungal infections

目的探讨慢性乙型重型肝炎合并真菌感染时抗真菌治疗的最佳治疗方案。方法将慢性乙型重型肝炎合并真菌感染的患者随机分成4组,每组方案连续治疗7d。治疗组给予每天口服氟康唑胶囊首剂0.4g,以后每次0.2g,每日3次,同时配合大蒜素注射液60mg加入5%葡萄糖500mL中静脉点滴,每日1次。对照1组单用大蒜素注射液60mg加入5%葡萄糖500mL中静脉点滴,每日1次。对照2组单用用氟康唑胶囊首剂0.4g,以后每次0.2g,每日3次。对照3组单用氟康唑注射液100mL(0.2g)静脉点滴,每日1次。结果治疗组在疗效/副作用的综合评价中同对照组相比具有显著的优越性。结论氟康唑联合大蒜素注射液是治疗慢性乙型重型肝炎合并真菌感染的理想治疗方案。

【Objective】 To inquire into the best plan in curing the patients of chronic severe hepatitis B together with fungal infections. 【Methods】 100 patients were divided into 4 groups. The treatment group was used by galic injection （60 mg galic injection＋5% Glucose 500 mL iv drip, qd） and fluconazole capsule （0.4 g for the first time, then 0.2 g for each time, 3 times a day）; the control group 1 was used by galic injection （60 mg galic injection＋5% Glucose 500 mL iv drip qd）; the control group 2 was used by fluconazole capsule （0.4 g for the first time, then 0.2 g for each time, 3 times a day）; the control group 3 was used by fluconazole injection （0.2 g iv drip, qd）. Observe the patients＇ change of the temperature, the liver level arid side effect. 【Results】 The ratio of the curative effect/side effect in the treatment was higher than the other groups. 【Conclusion】 Fluconazolc capsule and galic injection was ideal therapeutic plan for patients of chronic severe hepatitis B with fungal infections.