弓形虫隐性感染对精神分裂症患者临床表现的影响

Clinical Features of First-episode Schizophrenic Patients with and without Antitoxoplasma IgG

目的:通过比较弓形虫隐性感染和无弓形虫隐性感染的精神分裂症患者的临床表现,了解弓形虫感染与精神分裂症的关系。方法:通过酶联免疫吸附法检测600例首发精神分裂症患者血清弓形虫IgG抗体水平,并对患者进行阳性与阴性症状量表(PANSS)评定。结果:弓形虫IgG抗体阳性患者的PANSS阳性分量表(20·8±4·2,19·4±3·4,P<0·01)、阳性因子(26·6±3·3,25·7±3·3,P<0·05)、兴奋因子(9·5±3·8,7·9±3·9,P<0·01)和认知因子分(8·5±1·9,7·7±2·5,P<0·01)较弓形虫IgG抗体阴性的精神分裂症患者高,而阴性分量表分和阴性因子分较低(16·4±4·6,17·8±6·0,P<0·05;20·4±4·5,23·3±6·5,P<0·01)。结论:弓形虫慢性感染可能与精神分裂症的部分症状有关,具体关系待进一步流行病学研究证实。

Objective： To investigate the relationship between Toxoplasma infection and schizophrenia by comparing the clinical symptoms between the antitoxoplasma-seropositive and seronegative patients with schizophrenia. Methods： Six hundred cases of first-episode schizophrenia were examined the serum reactivity to IgG antitoxoplasma antibody by Enzyme Linked Immunosorbent Assay （ ELISA ） . And the clinical symptoms of the schizophrenic patients were scored by use of Positive and Negative Syndrome Scale （PANSS） . Results： Compared to IgG-seronegative schizophrenia, IgG-seropositive schizophrenia group was higher in the positive subscale score, the positive component score, the excitement component score, and the cognitive component score （20. 8 ±4. 2 ± 19.4 ±3.4, P 〈0.01; 26.6±3.3425.7±3.3, P〈0. 04; 9.5±3.847.9±3.9, P〈0. 01; 8.5±1.9±7.7±2.5, P〈 0. 01 ） ; and was lower in the negative subscle score and the negative component score （ 16. 4 ±4.6 ± 17.8 ±6. 0, P 〈 0. 05 ; 20. 4 ±4. 5 ± 23. 3 ± 6. 5, P 〈 0. 01 ） . Conclusion： Toxoplasma infection may be related with some of the symptoms of schizophrenia. Further epidemiological study is necessary to verify the findings.