葛根素注射液联合黄芪注射液治疗缺血性心脏病心力衰竭110例疗效观察

Observation on curative effect of puerarin injection(葛根素注射液) combined with astragalus injection(黄芪注射液) on heart failure in 110 patients with ischemic heart disease

目的:观察葛根素注射液联合黄芪注射液治疗缺血性心脏病心力衰竭的近期疗效。方法:220例缺血性心脏病心力衰竭患者按数字表法随机分为两组。对照组(110例)采用常规治疗,如血管紧张素转化酶抑制剂(ACE I)、洋地黄制剂、利尿剂、血管扩张剂等;治疗组(110例)应用葛根素注射液500 m g联合黄芪注射液40 m l静脉滴注,均每日1次;除不用洋地黄制剂、消心痛、硝酸甘油等扩血管药物外,其余治疗同对照组。两组均10 d为1个疗程,连用2个疗程,观察用药前后心率(HR)、心排血量(CO)、左室射血分数(LVEF)和左室舒张末期压力(LVEDP)等心功能参数,以及心功能分级、临床症状和体征的变化,两组药物不良反应等。结果:治疗组临床症状和体征均明显改善,与对照组比较差异均有显著性(P均<0.01);CO、LVEF明显改善,与对照组比较差异均有显著性(P<0.05和P<0.01);药物不良反应和毒性作用发生率(8.2%和0)明显低于对照组(23.6%和14.5%,P<0.05和P<0.01)。结论:葛根素注射液联合黄芪注射液治疗缺血性心脏病心力衰竭近期疗效显著,且无明显不良反应。

Objective： To observe the short -term effect of puerarin injection （葛根素注射液） combined with astragalus injection （黄芪注射液） on heart failure in patients with ischemic heart disease. Methods： Two hundred and twenty heart failure patients with isehemic heart disease were randomly divided into two groups. The control group was treated with conventional treatment, including angiotensin- converting enzyme inhibitor （ACEI）, digitalis, diuretic and vasodilators. The treatment group was treated with the same therapy as that in the control group, except vasodilator such as digitalis, isosorbide dinitrate, glonoin, and was additionally administered puerarin injection 500 ml combined with astragalus injection 40 ml for intravenous drip. Ten days were a therapeutic course and the patients were treated for courses in both groups. The cardiac function such as heart rate （HR）, cardiac output （CO）, left ventrieular ejection fraction （LVEF） and left ventricular end-diastolic pressure （LVEDP）, grade of cardiac function, clinical symptoms and signs before and after treatment, as well as the side -effects of medicine were observed. Results： The clinical symptoms, signs, CO, LVEF were improved in the treatment group, the differences were significant compared to the control group （P〈0. 05 or P〈0. 01）. The incidence rates of side -effect and toxic reaction in the treatment group （8. 2% and 0） were significantly lower than those of the control group （23.6% and 14.5%, P〈0. 05 and P〈0. 01）. Conclusion： Puerarin injection combined with astragalus injection for treatment of heart failure in patients with ischemic heart disease shows a significant short -term effect without side -effects.