葛根素合纳洛酮治疗外伤性脑梗死的临床疗效观察

Observation on curative effect of puerarin(葛根素) and naloxone(纳洛酮) for traumatic cerebral infarction

目的:观察葛根素与纳洛酮合用治疗外伤性脑梗死(TC I)的临床疗效。方法:52例TC I患者随机分为两组治疗。治疗组28例(单纯TC I 9例,合并脑挫伤颅内出血的TC I 19例)采用葛根素合纳洛酮治疗,对照组24例(单纯TC I 7例;合并脑挫伤、颅内出血的TC I 17例)采用常规治疗,比较两组疗效。结果:治疗组总有效率优于对照组(82.14%比62.50%,χ2=6.44,P<0.05),生活能力状态优于对照组(χ2=4.18,P<0.05)。治疗组中单纯TC I的治疗效果优于合并脑挫伤、颅内出血的TC I患者(P<0.05)。结论:葛根素与纳洛酮合用治疗TC I可提高疗效,对单纯TC I患者的疗效好于合并脑挫伤、颅内出血的TC I患者。

Objective： To observe the clinical therapeutic effects of Puerarin （葛根素） and naloxone （纳洛酮） in treatment for traumatic cerebral infarction （TCI）. Metbods： Fifty-two patients with TCI were randomly divided into two groups： treatment group （n=28, 9 eases with simple TCI and 19 cases with TCI complicated with cerebral contusion and intracranial hemorrhage） and control group （n= 24, 7 cases with simple TCI and 17 cases with TCI complicated with cerebral contusion and intracranial hemorrhage）. The therapeutic effects were compared between two groups. Results： The total effective rate in treatment group （82. 14%） was significantly higher than that in control group （62.50%, χ^2=6.44, P〈0.05）, while daily life activity in treatment group was superior to that of the control group （χ^2=4. 18, P〈0.05）. The curative effects in patients with simple TCI was higher than that of patients with TCI combined with brain contusion and intracranial hemorrhage in treatment group （χ^2= 4.30, P〈0. 05）. Conclusion： The combined use of puerarin and naloxone can significantly improve the curative effects of TCI, especially for the patients with simple TCI.