急慢性腹泻患者肠道菌群的改变

Intestinal flora changes in patients with acute or chronic diarrhea

目的探讨急慢性腹泻患者肠道菌群的变化及其差异。方法对20例慢性腹泻、31例急性腹泻及20例对照组的粪便进行肠杆菌、肠球菌、双歧杆菌、乳酸杆菌及类杆菌的培养及检测分析。结果与对照组比较,急性腹泻患者肠杆菌增加,肠球菌、双歧杆菌、乳酸杆菌及类杆菌减少(P<0.01),慢性腹泻患者肠杆菌增加,乳酸杆菌减少(P<0.05)。急性腹泻与慢性腹泻比较,类杆菌和乳酸杆菌减少更明显(P<0.05)。结论急慢性腹泻患者均存在肠道菌群失调,其中急性腹泻更严重。

Objective To investigate the intestinal flora changes in patients with acute or chronic diarrhea. Methods The feces from 20 patients with chronic diarrhea,31 patients with acute diarrhea and 20 healthy adults were cultured,the colony forming units of enteribaeilli ,enterococei ,bifidobacteria,laetobacilli and bacteroides were counted. Results Compared with the healthy adults, the colony forming units of enterobacterium increased and those of enterococeus, bifidobacterum, lactobacillum and bacteroides decreased in patients with acute diarrhea（ P 〈 0. 01 ）, and the colony forming units of enterobacterium increased and lactobacillum decreased in patients with chronic diarrhea, （P 〈 0.05 ）. Moreover, the number of colony forming units of hateroidcs and lactohacillum in patients with chronic diarrhea decreased less significantly than that in patients with acute patients P 〈 0.05）. Conclusion Patients with acute or chronic diarrhea have imbalances of intestinal flora, and the intestinal flora in patients with acute diarrhea was disturbed more than those patients with chronic diarrhea.