分子自组装氧化钛包覆硅球色谱柱载体的制备及正相色谱性能研究

Preparation and Normal-Phase Study of Core-shell Type TiO_2/SiO_2 Composite Spheres by Layer-by-layer Self-assemble Technique

采用分子自组装方法在微米硅球表面涂敷多层纳米二氧化钛,得到了比表面积为202.1 m2/g、孔体积0.3628 m3/g、孔径7 nm的复合颗粒。在正相条件下研究了该TiO2/S iO2壳核型复合微粒的色谱性能,并与ZrO2/S iO2复合微粒色谱性能进行了比较。结果表明:氧化钛复合颗粒渗透性好,柱压低,是一种比较理想的高效液相色谱载体,对中性化合物和碱性化合物有较好的分离选择性,峰形对称;但对酚类化合物强烈保留,峰形较差。

The uniform titania nanoparticle multilayers/micrometer-sized silica particle（TiO/SiO2 ）have been fabfabricated by consecutively assembling of surfactant C12 H25SO4Na（SDS） and titanium dioxide nanoparticles onto SiO2 micro beads and subsequently removing the surfactant by calcinations. The specific surface area, total pore volume, and average pore diameter of TiO2/SiO2 are 202.1 m^2/g, 0. 3628 cm^3/g and 7.0 nm, respectively. This titania supports was used to separate basic molecules, acidic molecules and non-basic isomeric aromatic mixtures under normal-phase conditions and compared with that of zirconia supports. It is shown that this enables the purification of basic fine chemicals and aromatic substances. The material exhibits good permeability,low back pressure, so it is an ideal packing for high performance liquid chromatographic applications.