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(S)-1-烯丙基-2-氨甲基吡咯烷的制备 被引量:1

Preparation of (S)-1-Allyl-2-aminomethylpyrrolidine
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摘要 (S)-1-Allyl-2-aminomethylpyrrolidine, a key intermediate of a novel dopamine D2-receptor PET imagingagent 18F-fallypride was prepared from L-prolinamide by allylation and reduction in an overall yield of 50%. (S) - 1-Allyl-2-aminomethylpyrrolidine, a key intermediate of a novel dopamine D2-receptor PET imaging agent ^18F-fallypride was prepared from L-prolinamide by allylation and reduction in an overall yield of 50%.
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2006年第2期84-84,144,共2页 Chinese Journal of Pharmaceuticals
基金 江苏省卫生厅科技资金(H200334)
关键词 (S)-1-烯丙基-2-氨甲基吡咯烷 制备 中间体 多巴胺 (S) -1-allyl-2-aminomethylpyrrolidine dopamine D2 -receptor intermediate preparation
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参考文献3

  • 1Mukherjee J, Yang ZY, Brown T, et al. Preliminary assessment of extrastiatal dopamine D-2 receptor binding in the rodent and nonhuman primate brains using the high affinity radioligand,^18F-fallypride [J]. Nucl Med Biol, 1999, 26 (5) :519-527.
  • 2Mukherjee J, Yang ZY, Das MK, et al. Fluorinated benzamide neuroleptics-Ⅲ. Developement of (S)-N-[ (1-allyl-2-pyrrolidinyl) methyl] -5- (3- [^18F] fluoropropyl) -2,3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer[J]. Nucl Med Biol, 1995, 22 (3): 283-296.
  • 3Hoegberg T, Raemsby S, Storem P. Efficient stereocon-servative syntheses of 1-substituted (S) -and (R) -2-aminomethylpyrrolidines [J]. Acta Chem Scand, 1989, 43(7) : 660-664.

同被引文献5

  • 1De Paulis T. The discovery of epidepride and its analogs as high affinity radioligands for imaging extrastriatal dopamine D2 receptors in human brain[J]. Curr Pharm Des, 2003, 9(8) : 673-696.
  • 2De Paulis T, Kessler RM. Radioiodinated benzamines and method of their use as radioimaging: US, 5480631 [P]. (CA 1996, 124: 139994)
  • 3Mukherjee J, Yang ZY, Das MK, et al. Fluorinated benzamide neuroleptics. Development of (S)-N-[ (1-allyl2-pyrrolidinyl) methyl] -5- (3-[^18F] fluoropropyl) -2,3-dimethoxybenzamide as an improved dopamine D2 receptor tracer [J].Nucl MedBiol, 1995, 22 (3) : 283-296.
  • 4杨敏,胡名扬,裴著果,王博诚,周杏琴.多巴胺D_2受体显像剂Epidepride的合成及其^(131)I标记[J].同位素,2001,14(2):65-70. 被引量:7
  • 5杨敏,胡名杨,裴著果,王博诚.Epidepride的合成[J].中国现代应用药学,2001,18(4):295-296. 被引量:1

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