摘要
The orthogonal design was used to optimize the formulation of helicid orally disintegrating tabletsprepared by direct powder compression method. The optimized formulation was as follows: weight ratio ofpolyvinylpolypyrrolidone and low-substituted hydroxypropylcellulose 1∶1; the amount of NaHCO3-citric acid(1∶1)14% and microcrystalline cellulose 10%. The prepared tablets disintegrated completely within 30s, dissolved in 2min andtasted fine.
The orthogonal design was used to optimize the formulation of helicid orally disintegrating tablets prepared by direct powder compression method, The optimized formulation was as follows： weight ratio of polyvinylpolypyrrolidone and low-substituted hydroxypropylcellulose 1 ; 1 ; the amount of NaHCO3-citric acid （1 ：1） 14 % and microcrystalline cellulose 10%. The prepared tablets disintegrated completely within 30s, dissolved in 2min and tasted fine.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2006年第2期99-100,共2页
Chinese Journal of Pharmaceuticals
