表面健康人群氨基末端B型利钠肽参考范围调查

NT-proBNP concentration in Chinese apparently healthy individuals

目的初步建立适合国人表面健康人群的氨基末端B型利钠肽(NTproBNP)的参考范围。方法体格检查和相关的实验室检查均无异常的表面健康人群共587名(男288名,女299名),按性别各分为<45岁、45～54岁、55～64岁、65～74岁和≥75岁5个年龄组。检测采用Elecsys2010电化学发光免疫分析仪和相应的检测试剂、校准品和质控品以及检测参数检测血清NTproBNP值并评价检测方法。结果NTproBNP的批内和天间的检测精密性良好,符合临床使用要求。表面健康人群NTproBNP水平随年龄增高呈逐渐上升趋势(P<0.05)。NTproBNP的参考范围在<65岁的女性组为<107ng/L,男性组为<78ng/L,≥65岁的女性组为<220ng/L,男性组为<148ng/L;在75岁以下各年龄组,女性NTproBNP水平显著高于男性(P<0.01)。结论国人表面健康人群的NTproBNP水平明显低于国外(欧美)人群。建立一个适合于国人的NTproBNP参考范围有重要的临床应用价值。

Objective To establish the distribution of peptide （NT-proBNP） by age and gender in apparently healthy automated Roche NT-proBNP assay was evaluated, and NT-proBNP serum N-terminal pro-brain natriuretic individuals-based study. Method The t and medical record review in 587 apparently healthy individuals （299 female and 288 male）were performed. Result The automated Roche NT-proBNP assay has good analytical performance. Within the apparently healthy individuals, the distribution of NT-proBNP differed by age and gender, and was higher in female than male （ P 〈 0. 01 ） under 75. The reference range of NT-proBNP was 〈 107 ng/L for women and 〈 78 ng/L for men aged 〈 65 years, and 〈220 ng/L for women and 〈 148 ng/L for men aged ≥65 years, which were lower than the data came from Western people. Conclusion Age,gender and ethnic NT-proBNP differences were demonstrated. Interpretation of NT-proBNP should include consideration of age-, gender-, and ethnic-specific partition values,