冠心病患者全血微量元素锌、铜、铁的分析

Analysis of Trace Elements Zn,Cu,Fe in the Whole Blood from Patients with Coronary Heart Disease

用原子吸收法测定５０例健康人、５２例冠心病患者全血微量元素锌、铜、铁的含量，并对５２例冠心病患者全血微量元素锌、铜、铁的含量及锌／铜比值，与其血脂总胆固醇（ＣＨ）、甘油三酯（ＴＧ）、高密度脂蛋白（ＨＤＬ）、低密度脂蛋白（ＬＤＬ）的浓度分别作线性相关分析。结果表明：（１）冠心病患者全血锌、铁、锌／铜比值均高于健康人（Ｐ＜０．０５），全血铜低于健康人（Ｐ＜０．０５）。（２）全血锌与ＨＤＬ呈负相关（Ｐ＜０．０１）、锌／铜比值与总胆固醇呈正相关（Ｐ＜０．０５），铁与ＬＤＬ呈正相关（Ｐ＜０．０１）．提示锌／铜比值增高及体内铁储存增加均可能是冠心病易患因素．

The contents of trace elements Zn.Cu,Fe in the whole blood from 52 cases of patients with coronary heart disease and 50 cases of healthy controls were determined by AAS.The linear correlation of the contents of trace elements Zn.Cu.Zn/Cu and Fe with CH.TG.HDL,LDL in the whole blood from the patients was analyzed.The results showed that the patients had higher contents of total blood Zn,Fe and Zn/Cu and lower content of Cu than those of the controls(P<0. 05).the total blood Zn had negative correlation with HDL(p<0.01),Zn/Cu had positive correlation with CH(P<0.05).Fe had positive correlation with LDL(P<0.05).It suggested that the increase of Zn/Cu and Fe could be one of the causes promoting coronary heart disease.