Graves’眼病^(131)I治疗后突眼的转归与TRAb及TGA、TMA的关系

Association of turnover of goggled-eye due to Graves' disease treated by ^(131)I with the blood levels of TRAb,TGA and TMA

目的探讨131I治疗G raves’病后突眼的转归与TRAb及TGA、TMA的关系,为临床治疗G raves’病后突眼提供理论参考。方法选择伴有突眼的G raves’病患者78例进行131I治疗,在治疗后第3、6、12个月进行随访,检测其TRAb及TGA、TMA浓度。结果治疗前TRAb及TGA、TMA水平高者,治疗后眼病获得改善的可能性较大;而治疗前TRAb及TGA、TMA水平低者,治疗后其活性变化不大,眼病的改善也不明显,差异有显著性。结论TRAb及TGA、TMA水平与突眼的发生和转归关系密切。

Objective To discuss the prognosis of goggled-geye caused by Graves＇disease after treated with ^131I and its association with the levels of TRAb, TGA and TMA in blood. Methods A total of 78 cases of Graves＇dlsease characterized by goggled-geyc were treated with ^131I, and visited at 3^th, 6^th and 12^th month after treatment. The blood levels of TRAb, TGA and TMA were tested betore treatment and during follow-gup. Results The patients with high blood levels of TRAb, TGA and TMA before ^131I treatment had a higher opportunity to get their eye symptoms improved, vice versa. There was a significant difference between the two kinds of patients. Conclusion The occurrence of goggled-geye and its turnover is closely related to the levels of TRAb, TGA and TMA.