同型半胱氨酸与冠心病、缺血性脑梗塞及老年性痴呆关系的研究

Relationship between Homocysteine and Coronary Heart Disease,Cerebral Infarction as well as Alzheimer's Disease

目的探讨血浆同型半胱氨酸(Hcy)水平变化与冠心病、缺血性脑梗塞和老年性痴呆(AD)的关系以及与血脂的相关性。方法分别测定48例急性缺血性脑梗塞、45例冠心病、47例AD和47例健康对照者的血浆Hcy以及血总胆固醇(TC)、三酰甘油(TG)、低密度胆固醇蛋白(LDL)和高密度胆固醇蛋白(HDL),并进行比较和相关性分析。结果缺血性脑梗塞组、冠心病组和AD组Hcy、TC、TG和LDL均高于对照组(P<0.01)。三组患者Hcy与TC、TG、LDL的关系进行简单直线相关分析显示,三组Hcy与TC、LDL和TG显著相关,但与HDL无相关。结论Hcy与冠心病、缺血性脑梗塞和AD密切关联,是心脑血管疾病的危险因子,检测血浆Hcy水平对冠心病、缺血性脑梗塞和AD的预防和治疗具有重要的临床价值。

Objective To investigate the relationship between the change of plasma homocysteine（Hcy） level and coronary heart disease（CHD） ,cerebral infarction as well as Alzheimer＇ s disease （AD） and its correlation with blood lipid. Method 48 cases of acute cerebral stroke,45 cases of CHD,47 cases of AD and 47 cases of normal control were recruited to participate the study. Their plasma total Hcy ,total cholesterol（TC） ,serum triglyceride （ TG）, low density lipoprotein-cholesterol （LDL-C） and high density lipoprotein-cholesterol （HDL-C） were measured respectively and statistically analyzed. Results Hcy, CH, TG and LDL-C levels were significantly higher in groups of CHD, acute cerebral stroke and AD than those in control group. Simple linear correlation analysis showed that there was a significant correlation between Hcy and TC,LDL,TG in three groups, while there was no correlation between Hcy and HDL. Conclusions Plasma Hcy level is closely related to CHD ,acute cerebral stroke and AD. It is a risk factor for cardiocerebral vascular diseases. It may be of important clinial value to determine plasma Hcy in the prevention and treatment of HCD, cerebral infarction and AD.