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局部亚低温对脑出血病人血清S-100B蛋白的影响

The Influence of Local Mild Hypothermia on Serum S-100B Protein of Patients with Cerebral Hemorrhage
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摘要 目的探讨局部亚低温治疗对脑出血病人血清S-100B蛋白的影响。方法将24例脑出血患者按1∶1配对分为亚低温组(12例)和对照组(12例),应用ELISA法检测24例脑出血病人(亚低温组12例,对照组12例)血清S-100B蛋白含量,同时检测11例正常人血清S-100B蛋白含量。结果脑出血病人血清S-100B蛋白含量明显高于正常人(P<0.05);局部亚低温治疗后脑出血病人亚低温组与对照组之间血清S-100B蛋白有显著性差异(P<0.05)。结论①急性脑出血病人血清S-100B蛋白水平较正常人高,因此S-100B蛋白可作为脑出血病情观察指标之一。②局部亚低温治疗能间接降低脑出血病人血清S-100B蛋白水平,从而发挥其脑保护作用。 OBJECTIVE To explore the influence of local mild hypothermia on serum S-100B protein of patients with cerebral hemorrhage. METHODES 24 patients with cerebral hemorrhage were divided into two groups （the mild hypothennia group and control group） by 1：1 partnership.The mild hypothermia group was 12 cases with local miht hypothemlia after routine therepy. The control group was 12 cases with routine therepy. The levels of serunl S-100B protein were analyzed by the use of ELISA assays in 24 patients with cerebral hemorrhage. Meanwhile the levels of serum S-100B protein were detected in 11 cases regular persons. RESULTS The levels of serum S- 100B protein in patients with cerehral hemon＇hage are higher than the levels of regular persons. There are significant differences in the levels of serum S-100B protein after 3days＇ and 7 days＇ treatment between the mild hypothermia group and the control group （P〈 0.05, respectively） . CONCLUSIONS Local mild hypothermia therapy can decrease the levels of serum S-100B protein in patients with cerebral hemorrhage indirectly.
作者 王悦 苏志强 赵庆杰 盛莉 董莉芹 彭艳彬 王德生
机构地区 黑龙江省第二医院 哈尔滨医科大学附属第一医院神经内科
出处 《中国初级卫生保健》 2006年第2期84-86,共3页 Chinese Primary Health Care
关键词 局部亚低温 脑出血 血清 S-100B蛋白 local mild hypothermia,cerebral hemorrhage,serum S-100B protein
分类号 R743.34 [医药卫生—神经病学与精神病学]
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参考文献9

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二级参考文献16

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中国初级卫生保健
2006年 第2期

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