灯盏花素治疗肺心病急性加重期的疗效及对凝血功能的影响

Curative effect of breviscapine on acute severe pulmonary heart disease and influence of it on coagulation

目的观察灯盏花素治疗肺心病急性加重期患者的临床疗效及对血液流变学、凝血功能的影响。方法对照组104例予以西医常规治疗,治疗组108例用西医常规加灯盏花素治疗,均连续用药15d。结果治疗组总有效率为91.67%,对照组为73.08%,差异有显著性(P<0.01)。全血低切黏度、高切黏度下降,氧分压上升,治疗组优于对照组(P<0.05);纤维蛋白原下降,活化部分凝血活酶时间延长,二氧化碳分压下降,治疗组明显优于对照组(P<0.01)。结论灯盏花素能明显改善症状、体征、心功能、血液流变学及凝血功能,在肺心病急性加重期的治疗过程中起重要辅助治疗作用。

Objective To observe the curative effect of breviseapine on acute severe pulmonary heart disease and the influence of it on hemorrheology and coagulation. Method The control group （n=104） was treated with routine western medicine and the treatment group （n=108） was treated with routine western medicine and breviscapine. Both groups were treated for 15 days. Result The total effective rate of the treatment group was 91.67 % and that of the control group was 73.08 %. The difference between two groups was significant （P〈0.01）. The treatment group was superior to the control group （P〈0.05） in the decrease of whole blood low shear viscosity, high shear viscosity and the increase of PaO2. The treatment group was superior to the control group（P〈0.01） in fibrinogen decrease, prolongation of activated partial thromboplastin time （APTT） and PaCO2 decrease . Conclusion Breviseapine relived the symptoms and signs, improved the heart function, hemorrhiology and coagulation, and played an important adjuvant role in the treatment of acute severe pulmonary heart disease.