2002-2004年我院抗抑郁药应用分析

Application Analysis of Antidepressants Used in Our Hospital During 2002-2004

目的:探讨抗抑郁药的使用特点及趋势,促进合理用药。方法:统计分析浙江省立同德医院2002-2004年使用抗抑郁药的品种、用量、销售总金额、用药频度、年平均增长率和药品日耗费用等情况。结果:销售总金额平均年增长率为16．79％,5-羟色胺再摄取抑制剂在 3年中平均年增长率高达34．44％;用药频度列前5位的药品有氯丙咪嗪、氟西汀、帕罗西汀、舍曲林及文拉法辛;新型抗抑郁药因其不良反应相对少而轻,治疗地位不断上升。结论:该院在抗抑郁药使用中还存在用药较为集中的问题,新型抗抑郁药应用前景广阔。

Objective： To investigate the change in using antidepressants in Tongde Hospital of Zhejiang Province during recent three years and to explore the characteristics and trend of use for more reasonable use of medicine. Methods： Statistical analyses of all the antidepressants used during the period of 2002--2004 in respect of medicine varieties, dosages, cost, frequency of drug use, annual average rate of growth（AARG） and daily drug expenses（DDE） were performed. Results： The AARG of antidepressants cost was 16.79% in this hospital during 3 years. The AARG of selective serotonin re-uptake inhibitors（SSRIs） was increased by 34.44% and the frequcency of drug use ranked 1st, 2nd, 3rd, 4th, 5th were： clomipramine, fluoxetine, paroxetine, sertraline and venlafaxine. The curative position of new antidepressants increased continuously because of the low incidence of adverse reaction. Conclusion： It is still a problem that the use of antidepressants is too concentrated, The new antidepressants will have a broad perspect at therapy.