摘要
目的研究拟青霉代谢物提取物(BCPT)对慢性不可预见性应激(CUS)抑郁模型大鼠海马和皮质中盐皮质激素受体(MR)、糖皮质激素受体(GR)mRNA表达的影响。方法采用CUS法建立大鼠抑郁模型,用逆转录-聚合酶链反应方法分别检测CUS模型大鼠海马和皮质中MR、GR mRNA的表达。结果BCPT可上调CUS模型大鼠皮质和海马中MR、GR mRNA的表达,降低MR/GR mRNA值。结论BCPT的抗抑郁作用可能与上述结果有关。
OBJECTIVE： To explore the antidepressant effects of bioactive compounds from paecilomyces tenuipes（BCPT） on expression of hippocampus and cortex mineralocorticoid receptor （MR）,glucoeorticoid receptor（GR）mRNA in CUS（chronic unpredictable stress） rats. METHODS： The depression model rat was produced by CUS, the therapy effect of BCPT was observed in CUS rats, It detected expression of hippocampus and cortex MR,GR mRNA with RT PCR in CUS rats.RESULTS： BCPT could enhance the expression of hippocampus and cortex MR,GR mRNA or decrease the ratio of MR/GR mRNA in CUS rats. CONCLUSION： BCPT could obviously enhance the expression of hippocampus and cortex MR, GR mRNA or decrease the ratio of MR/GR mRNA in CUS rats, the result of this study suggested that BCPT possess certain antidepressant effect.
出处
《中国药房》
CAS
CSCD
北大核心
2006年第3期177-179,共3页
China Pharmacy
基金
安徽省科技厅重点科研项目(04023048)
安徽省教育厅重点科研项目(2004KJ194ZD)
