乙型肝炎患者血清IL-6、IL-8、TNF-α水平与肝损程度、HBVDNA含量的相关性分析

To probe relation between different damages of liver tissue in patients and quantities of IL-6, IL-8, TNF-α in serum with hepatitis B

目的探讨乙型肝炎患者血清IL-6、IL-8、TNF-α含量与肝损程度及HBVDNA含量的相关性。方法107例乙型肝炎患者均做肝穿确定肝组织损害程度,检测血清IL-6、IL-8、TNF-α水平及HBVDNA含量。结果血清中IL-6、IL-8、TNF-α水平与HBVDNA含量呈正相关,随肝损程度加重,血清的IL-6、IL-8、TNF-α含量随之增加。结论乙型肝炎患者血清IL-6、IL-8、TNF-α水平与乙型肝炎肝脏损伤程度密切相关,是判定疗效和预后的重要指标。

[Objective] To probe the relation between different damages of liver tissue in patients and quantities of IL-6, IL-8, TNF-αn serum with hepatitis B. [Methods] The quantities of IL-6, IL-8, TNF-α were detected by ELISA; the DNA of virus was detected by amplisensor PCR assay system; the damages of liver tissue was detected by pathololgy. The statistics were tested. [Results] The quantitis of IL-6, IL-8, TNF-α and virus in serum were in- creased in patients with hepatitis B than that in control （P 〈0.01）. [Conalusion] All findings implied that IL-6, IL- 8 and TNF-α serum levels were related to the phases of hepatitis B and it reflected the extent of hepatocyte inflammation. So it can be used as an index to value the therapeutic effectiveness and to judge the patients prognosis.