氟西汀对产后抑郁患者血浆NPY含量的影响

Effect of fluoxetine on plasm neuropeptide in patients with postpartum depression

目的探讨氟西汀对产后抑郁患者血浆神经肽Y(NPY)含量的影响及其对抑郁障碍的改善作用。方法采用放免法测定60例产后抑郁患者治疗前后血浆NPY水平并评定治疗后抑郁症的改善情况。结果氟西汀治疗组抑郁好转或痊愈23例,安慰剂治疗组抑郁好转6例。氟西汀组治疗后的血浆NPY水平高于对照组(P<0.01)。结论氟西汀能改变产后抑郁患者血浆NPY水平,有明显改善抑郁作用。

[Objective] To explore the effect of Fluoxetine on neuropeptide Y（NPY） content in plasma and depressive symptom in patients with Postpartum deperesslon, [Methods] Radioimmunoassay technique was used for the measurement of plasma NPY level in sixty patients with postpartum depression at pre- and post-treatment. HAMD scale was used for the evaluation of depression condition in these patients at pre- and post-treatment. [Results] The depressive condition in 23 patients in Fluoxetine group were improved or cured, while 6 patients in control group were improved, The level of plasm neuropeptide in Fluoxetine group after treatment was significant higher than in control group（P 〈0.001）. [Conclusion] Fluoxefine can increase the plasma NPY level in patient with depression, and improve deprssive symptoms.