脑外伤患者血清可溶性P-选择素的变化及其意义

Changes of serum sP-selectin and its significance in patients with head injury

目的 研究脑外伤后P-选择素的变化和意义。方法 采用酶联免疫吸附法（ELISA）对25例重型脑外伤（GCS3～8）和18例轻-中型脑外伤（GCS9-15）连续测定伤后12、24、48、72h和第4天血清可溶性P-选择素（sPS）和预后评分（GOS）。观察sPS与GCS、GOS之间的联系。结果 重型脑外伤组在伤后12h sPS最高，连续3d高于正常（P〈0．05），升高水平明显高于轻-中型脑外伤组。伤后12h sPS；〉400ng／ml的病人预后明显不良（P〈0．05）。结论 P-选择素在脑外伤后明显升高，而且与预后相关。

Objective To investigate the changes of serum soluble P-selectin（sPS） in patients following head injury. Methods sPS was measured in 25 patients with Glasgow Coma Scale（GCS） score between 3-8 and 18 patients with GCS between 9-15 within 12,24,48,72 hours, 4 days after head injury by enzyme-linked immunosorbent assay（ELISA）. The relation between sPS and GCS, Glasgow Outcome Scale （GOS） were studied. Results sPS in patients with GCS between 3-8 was the highest within 12 hours after head injury（P〈0. 05）, and it was still higher on the 3rd day after head injury（P〈0.05）. The outcome of the patients with sPS〉400 ng/ml was poorer than that of the patients with sPS〈400 ng/ml （P〈0. 05）. Conclusion Serum level of sP-selectin is elevated in patients with head injury, which is correlated with the outcome of the patients.