摘要
本项研究观察了替硝唑对类杆菌，经腹腔感染小鼠的体内保护作用。结果显示替硝唑对脆弱类杆菌和产黑色素类杆菌感染的小鼠，均具有良好的保护作用，两株菌感染的半数有效剂量（ＥＤ５０）分别为１１．１５ｍｇ／ｋｇ和１３．０４ｍｇ／ｋｇ。与甲硝唑相比，两者无显著性差异。
In vivo effect of Tinidazole against Bacteroids was studied through intra-abdominal infection.The results showed that Tinidazole was very effective to the infections of B.fragilis and B.melaninogenicus in mice.The ED50 of Tinidazole against infections with B.fragilis and B.melaninogenicus was 11.15mg/kg and 13.04mg/kg,respectively.In comparision with Metronidazole,there is no difference between them.
出处
《中国微生态学杂志》
CAS
CSCD
1996年第2期14-16,共3页
Chinese Journal of Microecology
关键词
替硝唑
抗感染药
药理学
Tinidazole Anaerobic bacteria 50% Effective dose(ED50)
