精神分裂症患者长期服用氯氮平换用奎的平治疗的依从性研究

Compliance of quetiapine in treatment of schizophrenics having taken clozapine for long term

目的探讨精神分裂症患者长期服用氯氮平换用奎的平治疗的可行性、有效性及依从性。方法对17例服用氯氮平治疗的精神分裂症患者换用奎的平治疗,依据氯氮平剂量调整奎的平治疗剂量。采用临床总体印象量表于治疗前后评定临床疗效。结果换用奎的平治疗前后病情严重程度、总体疗效有所改善,差异有极显著性(t=3．158,P<0．01);不良反应少, 服药依从性好。结论氯氮平换用奎的平治疗精神分裂症效果满意,且安全、依从性好。

Objective To explore the workability, efficacy and compliance of quetiapine replacing elozapine in the treatment of schizophrenics who having taken clozapine for long term. Methods Clozapine was replaced by quetiapine in 17 schizophrenics taking clozapine and mean dosage of quetiapine regulated accord ing to dosage of clozapine. Before and after treatment, clinical effectiveness was assessed with the Clinical Global Impression（CGI）. Results After quetiapine replacement, severity and global effectiveness signifi- cantly improved, the difference was significant （t=3. 158, P〈0.01） ; quetiapine had fewer adverse effects and better compliance. Conclusion Quetiapine replacing clozapine in the treatment of schizophrenia has better effectiveness, higher safety and compliance.