季节对氯氮平血药浓度的影响

Effects of seasons on plasma-drug concentration of clozapine

目的探讨季节因素对氯氮平稳态血药浓度的影响。方法对108例长期服用氯氮平治疗的住院精神病患者的一般资料及1a内的定期血药浓度检测结果进行回顾性对比分析。结果氯氮平的平均血药浓度秋季最高,春季最低;春、夏、秋、冬四季血药浓度均有显著性差异(F=3．863,P=0．009),尤以夏季与春季(P=0．026),秋季与春季差异显著(P=0．001)。结论夏、秋季节可适当减少药物剂量,保证患者用药安全。

Objective To explore effects of seasons on steady plasma-drug concentration of clozapine. Methods Retrospective contrast analyses were conducted about general data and results of periodically measuring blood drug levels within one year in 108 in patients with psychosis who long-term clozapine used. Results Blood clozapine level was the highest in Autumn and lowest in Spring; there were significant difference in blood clozapine level among four seasons（F= 3. 863, P= 0. 009）, and differences especially significant between Summer and Spring（P=0. 026） as well as Autumn and Spring（P=0.001）. Conclusion Dosage could be appropriately reduced in Summer and Autumn in order to ensure safety for patients.