摘要
目的研究内毒素作用于新生大鼠后,肺组织CXCR4表达的变化及可能作用。方法用内毒素诱发7日龄新生大鼠急性肺损伤(ALI),免疫组织化学法检测肺组织中CXCR4及TNF-α蛋白水平的表达情况。结果正常新生大鼠肺组织中CXCR4及TNF-α蛋白呈阴性或弱阳性表达,LPS作用后,CXCR4及TNF-α蛋白的表达随着损伤严重程度的增加而增强。结论 CXCR4可能在新生大鼠急性肺损伤的发病中发挥一定的作用。
Objective： To investigate the expression of CXCR4 and its potential functions in neonatal rat lung caused by lipopolysacchafide （LPS）. Methods ： Though immunohistochemistry to detect the expression of CXCR4 and TNF-α in neonatal rat （7 days old） lung caused by LPS. Resuhs ： Normal neonatal lung weakly expressed CXCR4 and TNF-α protein. After the stimulation with LPS, the expression CXCR4 and TNF-α protein increased with the increased lung injury. Conclusion： CXCR4 may contribute to the process of acute lung injury and play roles on it.
出处
《中国优生与遗传杂志》
2006年第2期22-23,共2页
Chinese Journal of Birth Health & Heredity
